Property Summary

NCBI Gene PubMed Count 12
PubMed Score 3.22
PubTator Score 2.01

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 1.24282067199131E-17
malignant mesothelioma 3163 6.69697601703232E-9
pilocytic astrocytoma 3086 2.21079966076467E-7
osteosarcoma 7933 2.61186599853926E-4
invasive ductal carcinoma 2950 0.00102192930440386
interstitial cystitis 2299 0.00184790168130742
ductal carcinoma in situ 1745 0.00213824824428704
psoriasis 6685 0.00216868594447006
non primary Sjogren syndrome sicca 840 0.0254912463330988
spina bifida 1064 0.0299327671868887
Gaucher disease type 3 76 0.0412765505456237
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Alzheimer's disease 644 0.0 1.0

Expression

  Differential Expression (11)

Disease log2 FC p
malignant mesothelioma -3.300 0.000
psoriasis -1.300 0.002
osteosarcoma -3.913 0.000
interstitial cystitis 1.100 0.002
pilocytic astrocytoma 1.300 0.000
non primary Sjogren syndrome sicca -1.200 0.025
lung carcinoma -1.200 0.000
spina bifida 1.676 0.030
ductal carcinoma in situ -1.200 0.002
invasive ductal carcinoma -1.500 0.001
Gaucher disease type 3 -1.500 0.041

Synonym

Accession Q8TF62 Q9H727
Symbols ATPIM

Gene

PANTHER Protein Class (2)

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Platypus OMA EggNOG
C. elegans OMA Inparanoid

 GWAS Trait (1)

Gene RIF (3)

PMID Text
26473621 ATP8B4 gene was associated with a significant increase in the risk of systemic sclerosis. ATP8B4 is overexpressed in systemic sclerosis patients.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
17998437 Genome-wide association study of gene-disease association. (HuGE Navigator)

AA Sequence

MFCSEKKLREVERIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIP      1 - 70
EISSLTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWMNVKVGDIIKLEN     71 - 140
NQFVAADLLLLSSSEPHGLCYVETAELDGETNLKVRHALSVTSELGADISRLAGFDGIVVCEVPNNKLDK    141 - 210
FMGILSWKDSKHSLNNEKIILRGCILRNTSWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWI    211 - 280
FGFLICLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIR    281 - 350
LGHSYFINWDRKMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDD    351 - 420
LDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVHEFLRLLALCHTVMSEENSAGELIYQ    421 - 490
VQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSK    491 - 560
GADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIA    561 - 630
GLYEEIERDLMLLGATAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFV    631 - 700
IAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESD    701 - 770
VKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEGLQA    771 - 840
VLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLF    841 - 910
NIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNV    911 - 980
AGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPN    981 - 1050
QFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPTLSDQIRRWQKAQKKARPPSSRRPRT   1051 - 1120
RRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFSQDKTV   1121 - 1190
KL                                                                       1191 - 1192
//

Text Mined References (13)

PMID Year Title
26473621 2016 Identification of Rare Variants in ATP8B4 as a Risk Factor for Systemic Sclerosis by Whole-Exome Sequencing.
23087808 2012 Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study.
20961850 2010 CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.
20947505 2010 Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
17998437 2008 Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
16572171 2006 Analysis of the DNA sequence and duplication history of human chromosome 15.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12880872 2003 FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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