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  6. Serine/threonine-protein phosphatase 4 regulatory subunit 1

Tdark Serine/threonine-protein phosphatase 4 regulatory subunit 1

Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.

This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

 Comments

Property Summary

NCBI Gene PubMed Count 17
PubMed Score 4.71
PubTator Score 5.63

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Peripheral Neuropathy 303
Disease Target Count P-value
juvenile dermatomyositis 1189 1.14394128994466E-12
posterior fossa group B ependymoma 1530 6.32169671745559E-11
atypical teratoid/rhabdoid tumor 1095 3.9834403030545E-8
psoriasis 6685 7.1347293610487E-5
group 3 medulloblastoma 2254 1.51772569312099E-4
ovarian cancer 8492 1.52048345224973E-4
primitive neuroectodermal tumor 3031 1.55997520063835E-4
glioblastoma 5572 0.00196497470598816
Multiple myeloma 1328 0.00462316326896586
oligodendroglioma 2849 0.0281638100767384
Disease Target Count Z-score Confidence
Cardiovascular system disease 194 0.0 1.0

Expression

  Differential Expression (10)

Disease log2 FC p
Multiple myeloma 1.291 0.005
posterior fossa group B ependymoma 1.700 0.000
oligodendroglioma 1.300 0.028
psoriasis 1.600 0.000
group 3 medulloblastoma 1.500 0.000
glioblastoma 1.500 0.002
atypical teratoid/rhabdoid tumor 1.300 0.000
primitive neuroectodermal tumor 1.300 0.000
juvenile dermatomyositis 1.117 0.000
ovarian cancer 2.200 0.000

Synonym

Accession Q8TF05 Q99774 Q9UNQ7
Symbols MEG1
PP4R1
PP4(Rmeg)

Gene

PPP4R1

PANTHER Protein Class (3)

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
C. elegans EggNOG Inparanoid

 GO Function (1)

 GO Component (1)

 GO Process (3)

 Compartment GO Term (12)

 IMPC Term (3)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

 UniProt Keyword (6)

Gene RIF (3)

PMID Text
25134449 PP4R1 could mediate the dephosphorylation of TRAF2 Ser11.
23084358 PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK activity, T cell hyperactivation, and aberrant NF-kappaB signaling in NF-kappaB-addicted T cell lymphomas
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence 

MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSL      1 - 70
LDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYL     71 - 140
ADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITE    141 - 210
RLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVS    211 - 280
CATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRT    281 - 350
RDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAAS    351 - 420
NENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESE    421 - 490
GPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDI    491 - 560
NELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTD    561 - 630
PSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTA    631 - 700
ADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLL    701 - 770
ELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSG    771 - 840
RQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAV    841 - 910
EQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY                                  911 - 950
//

Text Mined References (20)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25134449 2014 The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-?B activation.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23084358 2012 A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.
21269460 2011 Initial characterization of the human central proteome.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
18715871 2008 PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
18614045 2008 A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
18347064 2008 Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
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