Tbio CEP192 Centrosomal protein of 192 kDa

Protein Summary

Description

Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).

Uniprot Accession IDs

• Q8TEP8
• A0A060A9S4
• B7ZMF0
• E9PF99
• Q8WYT8
• Q9H0F4
• Q9NW27
• Cep192

Gene Name

• CEP192

Ensembl ID

• ENST00000506447
• ENSP00000427550
• ENSG00000101639

Symbol

• KIAA1569
• PPP1R62

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
tissue	0.69
virus perturbation	0.68
cellular component	0.64
cell line	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.66   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.66   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0