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Tbio Short transient receptor potential channel 4-associated protein

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

 Comments

Property Summary

NCBI Gene PubMed Count 19
PubMed Score 23.93
PubTator Score 5.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
psoriasis 6694 1.6e-05
diabetes mellitus 1728 1.9e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Intestinal perforation 7 3.42 1.7

Expression

  Differential Expression (2)

Disease log2 FC p
diabetes mellitus -1.100 1.9e-03
psoriasis 2.100 1.6e-05

Synonym

Accession Q8TEL6 E1P5Q0 E1P5Q1 Q96H82 Q9BVB8 Q9H429 Q9UFS6 Trp4-associated protein
Symbols TRUSS
TRRP4AP
PPP1R158
C20orf188

Gene

TRPC4AP

  Ortholog (13)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (5)

 GO Function (2)

 GO Component (2)

 GO Process (4)

 Compartment GO Term (16)

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 IMPC Phenotype (1)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Pathway (6)

Protein-protein Interaction (22)

DDB1   CCDC6   PRRC2C   CUL4B   CUL4A   RBBP6   RNMT   PRRC2A   KLC1   HERC1   SMCHD1   KDM4D   IQGAP1   INTS14   SULF2   DDA1   SCAF11   SETD2   NOS1AP   MPZL1   NCOA1   EPB41L5  

Gene RIF (7)

AA Sequence 

MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSK      1 - 70
WSGIPQLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLL     71 - 140
VEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATL    141 - 210
IEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLG    211 - 280
PSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQ    281 - 350
ASIVFPPPGASEENGLPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGL    351 - 420
NNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLK    421 - 490
ANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGL    491 - 560
LEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRC    561 - 630
VTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLAR    631 - 700
RKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLN    701 - 770
PDRQSPSALVSYIEEPYMDIDRDFTEE                                               771 - 797
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Text Mined References (23)

PMID Year Title