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Tbio Short transient receptor potential channel 4-associated protein

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

 Comments

Property Summary

NCBI Gene PubMed Count 19
PubMed Score 23.93
PubTator Score 5.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 1.61126421635247E-5
diabetes mellitus 1663 0.00186743113719051
Disease Target Count Z-score Confidence
Intestinal perforation 6 3.448 1.7

Expression

  Differential Expression (2)

Disease log2 FC p
psoriasis 2.100 0.000
diabetes mellitus -1.100 0.002

Synonym

Accession Q8TEL6 E1P5Q0 E1P5Q1 Q96H82 Q9BVB8 Q9H429 Q9UFS6 Trp4-associated protein
Symbols TRUSS
TRRP4AP
PPP1R158
C20orf188

Gene

TRPC4AP

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG

 GO Function (2)

 GO Component (2)

 GO Process (3)

 Compartment GO Term (17)

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 HCA RNA Cell Line (56)

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Pathway (7)

 UniProt Keyword (5)

Gene RIF (7)

PMID Text
26038816 TRUSS is a novel substrate of E3 ligase Skp2.
20551172 TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus
20458742 These findings suggest that TNF-R1, TRUSS, and TRPC4 augment Ca(2+) loading of endoplasmic reticulum Ca(2+) stores in the context of m1AchR stimulation
19059308 The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years.
19059308 Observational study of gene-disease association. (HuGE Navigator)
18449908 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18449908 results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families

AA Sequence 

MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSK      1 - 70
WSGIPQLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLL     71 - 140
VEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATL    141 - 210
IEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLG    211 - 280
PSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQ    281 - 350
ASIVFPPPGASEENGLPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGL    351 - 420
NNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLK    421 - 490
ANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGL    491 - 560
LEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRC    561 - 630
VTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLAR    631 - 700
RKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLN    701 - 770
PDRQSPSALVSYIEEPYMDIDRDFTEE                                               771 - 797
//

Text Mined References (23)

PMID Year Title
26038816 2015 The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22703881 2012 Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
20551172 2010 Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.
20458742 2010 TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.
19966799 2010 A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
19389623 2009 Docking motif-guided mapping of the interactome of protein phosphatase-1.
19059308 2009 The frequency of the TRPC4AP haplotype in Alzheimer's patients.
18449908 2009 Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
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