Tbio MORC4 MORC family CW-type zinc finger protein 4

Protein Summary

Description

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q8TE76
• A1YR23
• A1YR24
• H7BXF1
• Q5JUK7
• Q96MZ2
• Q9HAI7

Gene Name

• MORC4

Ensembl ID

• ENST00000255495
• ENSP00000255495
• ENSG00000133131
• ENST00000355610
• ENSP00000347821

Symbol

• ZCW4
• ZCWCC2
• ZCW4
• ZCWCC2
• dJ75H8.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
disease perturbation	0.79
PubMedID	0.72
transcription factor perturbation	0.68
gene perturbation	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.74   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.74   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0