Tbio | A disintegrin and metalloproteinase with thrombospondin motifs 15 |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
pilocytic astrocytoma | 3086 | 3.09521391872748E-5 |
atypical teratoid / rhabdoid tumor | 4369 | 3.56123574330031E-5 |
posterior fossa group A ependymoma | 1511 | 7.77518147515354E-5 |
pediatric high grade glioma | 2712 | 0.00253899902687727 |
glioblastoma | 5572 | 0.00348466703518182 |
invasive ductal carcinoma | 2950 | 0.00480216137403202 |
Disease | log2 FC | p |
---|---|---|
atypical teratoid / rhabdoid tumor | 1.400 | 0.000 |
glioblastoma | 1.900 | 0.003 |
pediatric high grade glioma | 1.600 | 0.003 |
pilocytic astrocytoma | 1.400 | 0.000 |
posterior fossa group A ependymoma | 1.500 | 0.000 |
invasive ductal carcinoma | -1.994 | 0.005 |
Accession | Q8TE58 Q32MI6 ADAM-TS 15 |
Symbols |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
25649796 | ADAMTS15 is a candidate gene for intracranial aneurysms |
25099234 | ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4. |
23233679 | Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation. |
20590445 | ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene |
19458070 | ADAMTS15 may be target of inactivating mutations in human cancer. |
16152618 | ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma |
15599946 | negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer |
MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAFQEDFYLHLTP 1 - 70 DAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLP 71 - 140 NASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRA 141 - 210 KRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPK 211 - 280 VTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIED 281 - 350 DGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG 351 - 420 DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADG 421 - 490 TSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV 491 - 560 KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYV 561 - 630 LAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVV 631 - 700 AIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQ 701 - 770 ASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP 771 - 840 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCG 841 - 910 RGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 911 - 950 //
PMID | Year | Title |
---|---|---|
26870338 | 2016 | ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4. |
25649796 | 2015 | Genetic study of intracranial aneurysms. |
25099234 | 2015 | Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. |
24024966 | 2013 | Genome-wide association study of chronic periodontitis in a general German population. |
23233679 | 2013 | Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. |
20590445 | 2010 | Androgen regulates ADAMTS15 gene expression in prostate cancer cells. |
19458070 | 2009 | Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. |
16959974 | 2006 | The consensus coding sequences of human breast and colorectal cancers. |
16152618 | 2006 | ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. |
15599946 | 2005 | The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. |
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