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  6. A disintegrin and metalloproteinase with thrombospondin motifs 15

Tbio A disintegrin and metalloproteinase with thrombospondin motifs 15

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 14
PubMed Score 5.17
PubTator Score 5.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8

Expression

  Differential Expression (6)

Disease log2 FC p
adult high grade glioma 1.600 8.0e-04
Astrocytoma, Pilocytic 1.400 3.0e-05
atypical teratoid / rhabdoid tumor 1.400 3.6e-05
glioblastoma 1.900 3.5e-03
invasive ductal carcinoma -1.994 4.8e-03
posterior fossa group A ependymoma 1.500 7.8e-05

Synonym

Accession Q8TE58 Q32MI6 ADAM-TS 15
Symbols

Gene

ADAMTS15

PANTHER Protein Class (3)

  Ortholog (13)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG

 UniProt Keyword (16)

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 GO Function (4)

 GO Component (3)

 Compartment GO Term (7)

 HCA RNA Cell Line (45)

See all...

 CSPA Cell Line (2)

Pathway (8)

Gene RIF (9)

AA Sequence 

MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAFQEDFYLHLTP      1 - 70
DAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLP     71 - 140
NASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRA    141 - 210
KRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPK    211 - 280
VTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIED    281 - 350
DGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG    351 - 420
DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADG    421 - 490
TSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV    491 - 560
KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYV    561 - 630
LAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVV    631 - 700
AIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQ    701 - 770
ASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP    771 - 840
ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCG    841 - 910
RGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC                                  911 - 950
//

Text Mined References (15)

PMID Year Title