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  6. A disintegrin and metalloproteinase with thrombospondin motifs 15

Tbio A disintegrin and metalloproteinase with thrombospondin motifs 15

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 5.02
PubTator Score 5.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
pilocytic astrocytoma 3086 3.09521391872748E-5
atypical teratoid / rhabdoid tumor 4369 3.56123574330031E-5
posterior fossa group A ependymoma 1511 7.77518147515354E-5
pediatric high grade glioma 2712 0.00253899902687727
glioblastoma 5572 0.00348466703518182
invasive ductal carcinoma 2950 0.00480216137403202

Expression

  Differential Expression (6)

Disease log2 FC p
atypical teratoid / rhabdoid tumor 1.400 0.000
glioblastoma 1.900 0.003
pediatric high grade glioma 1.600 0.003
pilocytic astrocytoma 1.400 0.000
posterior fossa group A ependymoma 1.500 0.000
invasive ductal carcinoma -1.994 0.005

Synonym

Accession Q8TE58 Q32MI6 ADAM-TS 15
Symbols

Gene

ADAMTS15

PANTHER Protein Class (3)

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GO Function (4)

 GO Component (3)

 Compartment GO Term (8)

 HCA RNA Cell Line (45)

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 CSPA Cell Line (2)

Pathway (8)

 UniProt Keyword (16)

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Gene RIF (7)

PMID Text
25649796 ADAMTS15 is a candidate gene for intracranial aneurysms
25099234 ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4.
23233679 Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation.
20590445 ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene
19458070 ADAMTS15 may be target of inactivating mutations in human cancer.
16152618 ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma
15599946 negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer

AA Sequence 

MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAFQEDFYLHLTP      1 - 70
DAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLP     71 - 140
NASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRA    141 - 210
KRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPK    211 - 280
VTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIED    281 - 350
DGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG    351 - 420
DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADG    421 - 490
TSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV    491 - 560
KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYV    561 - 630
LAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVV    631 - 700
AIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQ    701 - 770
ASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP    771 - 840
ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCG    841 - 910
RGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC                                  911 - 950
//

Text Mined References (13)

PMID Year Title
26870338 2016 ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4.
25649796 2015 Genetic study of intracranial aneurysms.
25099234 2015 Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
24024966 2013 Genome-wide association study of chronic periodontitis in a general German population.
23233679 2013 Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion.
20590445 2010 Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
19458070 2009 Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16152618 2006 ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
15599946 2005 The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.
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