| Tbio | A disintegrin and metalloproteinase with thrombospondin motifs 15 |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 3.0e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.6e-05 |
| posterior fossa group A ependymoma | 468 | 7.8e-05 |
| adult high grade glioma | 3801 | 8.0e-04 |
| glioblastoma | 5792 | 3.5e-03 |
| invasive ductal carcinoma | 2950 | 4.8e-03 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.600 | 8.0e-04 |
| Astrocytoma, Pilocytic | 1.400 | 3.0e-05 |
| atypical teratoid / rhabdoid tumor | 1.400 | 3.6e-05 |
| glioblastoma | 1.900 | 3.5e-03 |
| invasive ductal carcinoma | -1.994 | 4.8e-03 |
| posterior fossa group A ependymoma | 1.500 | 7.8e-05 |
MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAFQEDFYLHLTP 1 - 70 DAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLP 71 - 140 NASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRA 141 - 210 KRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPK 211 - 280 VTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIED 281 - 350 DGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG 351 - 420 DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADG 421 - 490 TSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV 491 - 560 KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYV 561 - 630 LAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVV 631 - 700 AIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQ 701 - 770 ASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP 771 - 840 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCG 841 - 910 RGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 911 - 950 //
