| Tbio | Elongator complex protein 5 |
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 3.2e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.3e-02 |
| group 3 medulloblastoma | 4104 | 1.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Riley-Day syndrome | 11 | 3.608 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.300 | 1.9e-02 |
| osteosarcoma | -1.019 | 3.2e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.244 | 1.3e-02 |
MTPSEGARAGTGRELEMLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFRE 1 - 70 GFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQ 71 - 140 VLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRP 141 - 210 TDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQ 211 - 280 QALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI 281 - 316 //
