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Tbio Elongator complex protein 5

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 7.64
PubTator Score 2.70

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
osteosarcoma 7933 0.00321968330581497
pancreatic ductal adenocarcinoma liver metastasis 1795 0.012698246225107
group 3 medulloblastoma 2254 0.0193080090471952

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -1.019 0.003
pancreatic ductal adenocarcinoma liver m... -1.244 0.013
group 3 medulloblastoma 1.300 0.019

Synonym

Accession Q8TE02 A8K1M5 D3DTN9 Q659B6 Q7Z2T4 Q8TDR9 Q9BUB2 Q9Y2Q4
Symbols DERP6
MST071
HSPC002
MSTP071
C17orf81

Gene

ELP5

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid

 GO Component (3)

 GO Process (3)

 Compartment GO Term (15)

 HCA RNA Cell Line (56)

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Pathway (4)

 UniProt Keyword (9)

Gene RIF (2)

PMID Text
22854966 data identify DERP6/ELP5 and C3ORF75/ELP6 as key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator.
16850183 cloning and characterization of the DERP6 gene, isolated from testis cDNA library; results indicate that the DERP6 may be involved in p53-mediated gene transcription

AA Sequence 

MTPSEGARAGTGRELEMLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFRE      1 - 70
GFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQ     71 - 140
VLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRP    141 - 210
TDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQ    211 - 280
QALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI                                      281 - 316
//

Text Mined References (15)

PMID Year Title
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22854966 2012 DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16850183 2006 Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
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