| Tdark | Volume-regulated anion channel subunit LRRC8C |
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.8e-12 |
| tuberculosis | 2010 | 2.1e-05 |
| ulcerative colitis | 1819 | 4.4e-05 |
| cystic fibrosis | 1696 | 6.6e-05 |
| osteosarcoma | 7950 | 5.7e-04 |
| interstitial cystitis | 2312 | 1.2e-03 |
| medulloblastoma, large-cell | 6241 | 1.3e-03 |
| ductal carcinoma in situ | 1745 | 1.6e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.7e-03 |
| astrocytic glioma | 2597 | 4.8e-03 |
| invasive ductal carcinoma | 2951 | 5.9e-03 |
| group 3 medulloblastoma | 4104 | 6.2e-03 |
| oligodendroglioma | 2850 | 7.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.2e-02 |
| sarcoidosis | 370 | 2.2e-02 |
| ependymoma | 4679 | 4.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.500 | 4.8e-03 |
| cystic fibrosis | 1.384 | 6.6e-05 |
| ductal carcinoma in situ | -1.200 | 1.6e-03 |
| ependymoma | -1.100 | 4.1e-02 |
| group 3 medulloblastoma | -1.300 | 6.2e-03 |
| interstitial cystitis | 1.300 | 1.2e-03 |
| intraductal papillary-mucinous adenoma (... | -1.400 | 1.7e-03 |
| intraductal papillary-mucinous carcinoma... | -1.600 | 2.7e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 2.2e-02 |
| invasive ductal carcinoma | -1.400 | 5.9e-03 |
| medulloblastoma, large-cell | -2.000 | 1.3e-03 |
| oligodendroglioma | -1.400 | 7.3e-03 |
| osteosarcoma | 1.805 | 5.7e-04 |
| ovarian cancer | 1.900 | 2.8e-12 |
| sarcoidosis | 1.100 | 2.2e-02 |
| tuberculosis | -1.200 | 2.1e-05 |
| ulcerative colitis | 2.100 | 4.4e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSN 1 - 70 VSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFML 71 - 140 CSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEDSLVNS 141 - 210 QSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYN 211 - 280 SALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYS 281 - 350 FEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT 351 - 420 NAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLK 421 - 490 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAV 491 - 560 VDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEI 561 - 630 VSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPP 631 - 700 EIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 701 - 770 LGDCRALKRAGLVVEDALFETLPSDVREQMKTE 771 - 803 //
