| Tdark | Volume-regulated anion channel subunit LRRC8C |
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Comments
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.500 | 0.005 |
| ependymoma | -1.100 | 0.041 |
| oligodendroglioma | -1.400 | 0.007 |
| osteosarcoma | 1.805 | 0.001 |
| group 3 medulloblastoma | -2.200 | 0.002 |
| cystic fibrosis | 1.801 | 0.000 |
| medulloblastoma, large-cell | -2.000 | 0.001 |
| tuberculosis | -1.200 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -1.400 | 0.002 |
| intraductal papillary-mucinous carcinoma... | -1.600 | 0.003 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 0.022 |
| sarcoidosis | 1.100 | 0.022 |
| interstitial cystitis | 1.600 | 0.000 |
| ductal carcinoma in situ | -1.200 | 0.002 |
| invasive ductal carcinoma | -1.700 | 0.002 |
| ulcerative colitis | 2.100 | 0.000 |
| ovarian cancer | 1.900 | 0.000 |
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSN 1 - 70 VSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFML 71 - 140 CSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEDSLVNS 141 - 210 QSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYN 211 - 280 SALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYS 281 - 350 FEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT 351 - 420 NAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLK 421 - 490 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAV 491 - 560 VDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEI 561 - 630 VSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPP 631 - 700 EIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 701 - 770 LGDCRALKRAGLVVEDALFETLPSDVREQMKTE 771 - 803 //
| PMID | Year | Title |
|---|---|---|
| 26824658 | 2016 | LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. |
| 24790029 | 2014 | Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. |
| 24529757 | 2014 | Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22532330 | 2012 | LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 19946888 | 2010 | Defining the membrane proteome of NK cells. |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
| 15564382 | 2004 | Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| More... |
