Tchem OXER1 Oxoeicosanoid receptor 1

Protein Summary

Description

Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Uniprot Accession IDs

• Q8TDS5
• Q86WP7
• Q8NGW4

Gene Name

• OXER1

Ensembl ID

• ENST00000378661
• ENSP00000367930
• ENSG00000162881

Symbol

• GPR170
• TG1019
• GPCR
• GPR170
• TG1019

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
tissue sample	0.66
cell type or tissue	0.56
ligand (chemical)	0.51
pathway	0.47

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Oxoeicosanoid Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.18   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.18   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0