Tchem STK35 Serine/threonine-protein kinase 35

Protein Summary

Description

The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDR2
• B2RBM3
• C7ENV8
• Q2NKW6
• Q5T3R1
• Q5T3R2
• Q96AB4
• Q9BZ06

Gene Name

• STK35

Ensembl ID

• ENST00000381482
• ENSP00000370891
• ENSG00000125834

Symbol

• CLIK1
• PDIK1
• STK35L1
• CLIK1
• STK35L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
transcription factor binding site profile	0.88
microRNA	0.83
PubMedID	0.64
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase 35

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nkf4 Family / Serine/threonine-protein Kinase 35

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1