You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GNPDA2
Glucosamine-6-phosphate isomerase 2

Protein Summary
Description
The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295448
  • ENSP00000295448
  • ENSG00000163281
  • ENST00000507534
  • ENSP00000427423
  • ENST00000507917
  • ENSP00000425868
  • ENST00000509756
  • ENSP00000424061

Symbol
  • GNP2
  • GNP2
  • SB52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.77
kinase perturbation
0.76
transcription factor perturbation
0.68
microRNA
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.51   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.51   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0