Property Summary

NCBI Gene PubMed Count 7
Grant Count 6
Funding $598,781.25
PubMed Score 6.37
PubTator Score 2.83

Knowledge Summary

Patent

No data available

TINX Plot

Expression

  Differential Expression (1)

Disease log2 FC p
Atopic dermatitis -1.600 0.001

Synonym

Accession Q8TDN7 AlkCDase 1
Symbols ASAH3
ALKCDase1

Gene

PANTHER Protein Class (1)

Gene RIF (2)

PMID Text
17713573 upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of keratinocytes by generating sphingosine and its phosphate
11915342 regulates the signaling system mediated by sphingolipids

AA Sequence

MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIYVVWVLFMIIG      1 - 70
LFSMYFHMTLSFLGQLLDEIAILWLLGSGYSIWMPRCYFPSFLGGNRSQFIRLVFITTVVSTLLSFLRPT     71 - 140
VNAYALNSIALHILYIVCQEYRKTSNKELRHLIEVSVVLWAVALTSWISDRLLCSFWQRIHFFYLHSIWH    141 - 210
VLISITFPYGMVTMALVDANYEMPGETLKVRYWPRDSWPVGLPYVEIRGDDKDC                    211 - 264
//

Text Mined References (7)

PMID Year Title
20628055 2010 Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.
17713573 2008 Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes.
17562024 2007 Large-scale identification of human genes implicated in epidermal barrier function.
16477081 2006 Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12783875 2003 Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.