Tclin KCNV2 Potassium voltage-gated channel subfamily V member 2

Protein Summary

Description

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDN2
• Q5T6X0

Gene Name

• KCNV2

Ensembl ID

• ENST00000382082
• ENSP00000371514
• ENSG00000168263

Symbol

• Kv8.2
• RCD3B
• KV11.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.79
cell line	0.72
tissue sample	0.69
cell type or tissue	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / V Subfamily / Kv8.2/kcnv2 Sub-subfamily / Potassium Voltage-gated Channel Subfamily V Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.56   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.56   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3