Tbio SP7 Transcription factor Sp7

Protein Summary

Description

Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q8TDD2
• B3KY26
• Q3MJ72
• Q7Z718

Gene Name

• SP7

Ensembl ID

• ENST00000303846
• ENSP00000302812
• ENSG00000170374
• ENST00000536324
• ENSP00000443827
• ENST00000537210
• ENSP00000441367

Symbol

• OSX
• OSX
• OI11
• OI12
• osterix

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.61
transcription factor	0.57
microRNA	0.55
cell line	0.51
disease	0.48

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Transcription Factor Sp7

Protein / Transcription Factor / Transcription Cofactor / Transcription Factor Sp7

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp7

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1154.9   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1154.9   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0