Tchem BRSK1 Serine/threonine-protein kinase BRSK1

Protein Summary

Description

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Uniprot Accession IDs

• Q8TDC3
• F1DG44
• Q5J5B5
• Q8NDD0
• Q8NDR4
• Q8TDC2
• Q96AV4
• Q96JL4

Gene Name

• BRSK1

Ensembl ID

• ENST00000309383
• ENSP00000310649
• ENSG00000160469
• ENST00000585418
• ENSP00000467357
• ENST00000590333
• ENSP00000468190

Symbol

• KIAA1811
• SAD1
• SADB
• hSAD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.85
cellular component	0.64
tissue sample	0.59
biological process	0.58

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Brsk1

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / Brsk Subfamily / Serine/threonine-protein Kinase Brsk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.74   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 412   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.74   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0