Tchem TRPM4 Transient receptor potential cation channel subfamily M member 4

Protein Summary

Description

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q8TD43
• A2RU25
• Q7Z5D9
• Q96L84
• Q9NXV1
• hTRPM4

Gene Name

• TRPM4

Ensembl ID

• ENST00000252826
• ENSP00000252826
• ENSG00000130529
• ENST00000427978
• ENSP00000407492

Symbol

• LTRPC4
• LTrpC4
• PFHB1B
• TRPM4B
• hTRPM4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
biological process	0.72
gene perturbation	0.68
cell line	0.66
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily M Member 4

Protein / Receptor / Transient Receptor Potential Cation Channel Subfamily M Member 4

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Ltrpc Subfamily / Trpm4 Sub-subfamily / Transient Receptor Potential Cation Channel Subfamily M Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.8   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.8   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4