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Tbio
CCHCR1
Coiled-coil alpha-helical rod protein 1

Protein Summary
Description
May be a regulator of keratinocyte proliferation or differentiation. This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376266
  • ENSP00000365442
  • ENSG00000204536
  • ENST00000383341
  • ENSP00000372832
  • ENSG00000206355
  • ENST00000383527
  • ENSP00000373019
  • ENSG00000206457
  • ENST00000396268
  • ENSP00000379566
  • ENST00000400352
  • ENSP00000383205
  • ENST00000400412
  • ENSP00000383263
  • ENST00000416163
  • ENSP00000408012
  • ENSG00000234114
  • ENST00000425620
  • ENSP00000393042
  • ENST00000451521
  • ENSP00000401039

Symbol
  • C6orf18
  • HCR
  • HCR
  • SBP
  • pg8
  • C6orf18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
disease perturbation
0.74
phenotype
0.73
virus
0.66
cellular component
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.36   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.36   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0