Tbio CD99L2 CD99 antigen-like protein 2

Protein Summary

Description

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q8TCZ2
• A8K2D5
• A8K5R0
• B3KWG2
• B4DDL7
• E7EMK5
• E9PD27
• Q8TAW2
• Q8TCZ0
• Q8TCZ1
• Q9BQG9

Gene Name

• CD99L2

Ensembl ID

• ENST00000346693
• ENSP00000489222
• ENSG00000102181
• ENST00000355149
• ENSP00000347275
• ENST00000370377
• ENSP00000359403
• ENST00000437787
• ENSP00000394858
• ENST00000466436
• ENSP00000417697
• ENST00000613030
• ENSP00000480322

Symbol

• MIC2L1
• CD99B
• MIC2L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
disease perturbation	0.87
transcription factor perturbation	0.74
kinase perturbation	0.71
cellular component	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.19   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.19   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0