Tbio | Rhophilin-1 |
Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity).
Comments
Disease | Target Count |
---|---|
Polycystic Ovary Syndrome | 335 |
Disease | Target Count | P-value |
---|---|---|
lung adenocarcinoma | 2714 | 1.92017728376943E-6 |
ovarian cancer | 8492 | 1.17213547755679E-4 |
breast carcinoma | 1614 | 6.14836174174115E-4 |
inflammatory breast cancer | 404 | 0.0184210523701573 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Opisthorchiasis | 14 | 4.089 | 2.0 |
Disease | log2 FC | p |
---|---|---|
breast carcinoma | 1.200 | 0.001 |
lung adenocarcinoma | 1.500 | 0.000 |
inflammatory breast cancer | 1.100 | 0.018 |
ovarian cancer | -1.200 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA Inparanoid |
Fruitfly | EggNOG Inparanoid |
PMID | Text |
---|---|
19403673 | The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule |
MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETV 1 - 70 ALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGAS 71 - 140 YEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALA 141 - 210 FEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLM 211 - 280 MAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEY 281 - 350 FRSLAHYHVAMALCDGSRECPPHLPMVLPRPPRAGSQPLCPPAATEGELPTHEQVFLQPPTSSKPRGPVL 351 - 420 PQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAE 421 - 490 APDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLI 491 - 560 AAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPV 561 - 630 LLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 631 - 695 //
PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
16189514 | 2005 | Towards a proteome-scale map of the human protein-protein interaction network. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14749388 | 2004 | Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
12221077 | 2002 | The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. |
11572484 | 2001 | Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. |
10591629 | 2000 | Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. |