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Tbio Rhophilin-1

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 6.03
PubTator Score 3.34

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Polycystic Ovary Syndrome 335
Disease Target Count P-value
lung adenocarcinoma 2714 1.92017728376943E-6
ovarian cancer 8492 1.17213547755679E-4
breast carcinoma 1614 6.14836174174115E-4
inflammatory breast cancer 404 0.0184210523701573
Disease Target Count Z-score Confidence
Opisthorchiasis 14 4.089 2.0

Expression

  Differential Expression (4)

Disease log2 FC p
breast carcinoma 1.200 0.001
lung adenocarcinoma 1.500 0.000
inflammatory breast cancer 1.100 0.018
ovarian cancer -1.200 0.000

Synonym

Accession Q8TCX5 Q8TAV1 Q96PV9
Symbols ODF5
RHPN
RHOPHILIN

Gene

RHPN1

PANTHER Protein Class (2)

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid
Fruitfly EggNOG Inparanoid

 GO Component (1)

 GO Process (1)

 Compartment GO Term (10)

 IMPC Term (2)

 MGI Term (1)

 HCA RNA Cell Line (46)

See all...

Pathway (6)

 UniProt Keyword (4)

Gene RIF (1)

PMID Text
19403673 The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule

AA Sequence 

MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETV      1 - 70
ALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGAS     71 - 140
YEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALA    141 - 210
FEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLM    211 - 280
MAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEY    281 - 350
FRSLAHYHVAMALCDGSRECPPHLPMVLPRPPRAGSQPLCPPAATEGELPTHEQVFLQPPTSSKPRGPVL    351 - 420
PQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAE    421 - 490
APDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLI    491 - 560
AAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPV    561 - 630
LLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP         631 - 695
//

Text Mined References (8)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14749388 2004 Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12221077 2002 The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization.
11572484 2001 Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.
10591629 2000 Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.