Property Summary

NCBI Gene PubMed Count 19
Grant Count 17
R01 Count 9
Funding $1,464,977.34
PubMed Score 22.11
PubTator Score 12.11

Knowledge Summary


No data available



  Differential Expression (4)

Disease log2 FC p
osteosarcoma -1.140 0.000
juvenile dermatomyositis 1.026 0.000
ovarian cancer 1.200 0.001
pituitary cancer 1.200 0.000

Gene RIF (9)

25827571 Secretome analysis identifies novel signal Peptide peptidase-like 3 substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
25827571 SPPL3 substrates identified on a proteome-wide scale in human and murine cells include numerous glycan-modifying enzymes residing in the Golgi network and implicated in distinct glycosylation pathways, including N-glycosylation, mucin-type O-glycosylation, O-mannosylation and glycosaminoglycan biosynthesis.
25384971 SPPL3 enhances the signal-induced association of stromal interaction molecule 1
25354954 Authors demonstrate that SPPL3 alters the pattern of cellular N-glycosylation by triggering the proteolytic release of active site-containing ectodomains of glycosidases and glycosyltransferases.
25354954 SPPL3 cleaves Golgi type II membrane proteins leading to their secretion. SPPL3 substrates include Golgi glycosyltransferases MGAT5, B4GALT1, and B3GNT1. By facilitating disengagement of these glycosyltransferases from their membrane anchors, SPPL3 causes their premature secretion and consequently orchestrates the extent of N-glycosylation on human and murine cells.
23132852 human SPPL3 is the first GxGD-type aspartyl protease shown to be capable of acting like a sheddase, similar to members of the rhomboid family, which belong to the class of intramembrane-cleaving serine proteases.
16873890 SPPL3 cleaves a SPP substrate, but a more distantly related homologue SPPL2b does not, providing strong evidence that the malaria SPP and human SPPL3 have conserved active sites, while the active sites SPPL2b is distinct
15998642 SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.
15385547 SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

AA Sequence

TLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV                                       351 - 385

Text Mined References (20)

PMID Year Title
25827571 2015 Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.
25384971 2015 A protease-independent function for SPPL3 in NFAT activation.
25354954 2014 Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.
23132852 2012 Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19197348 2009 Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
17965014 2008 Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
16873890 2006 Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
16829952 2006 SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
15998642 2005 Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.