Tbio PIFO Protein pitchfork

Protein Summary

Description

During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.

Uniprot Accession IDs

• Q8TCI5
• D9J0A2
• D9J0A3
• Q4G0K4
• Q52LJ6
• Q5T5D5
• Q5T5D6
• Q8N310

Gene Name

• PIFO

Ensembl ID

• ENST00000369737
• ENSP00000358752
• ENSG00000173947
• ENST00000369738
• ENSP00000358753

Symbol

• C1orf88
• C1orf88
• pitchfork

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.73
cellular component	0.69
cell line	0.57
molecular function	0.53
PubMedID	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 4   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0