ZFAND1
AN1-type zinc finger protein 1
Protein Summary
Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).
- ENST00000220669
- ENSP00000220669
- ENSG00000104231
- ENST00000519523
- ENSP00000429167
- ENST00000521287
- ENSP00000428139
- ENST00000522520
- ENSP00000429999
- ENST00000523096
- ENSP00000430736
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
histone modification site profile | 0.76 | ||
tissue sample | 0.63 | ||
gene perturbation | 0.53 | ||
tissue | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.61 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 22 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.61 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 22 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0