Property Summary

NCBI Gene PubMed Count 38
Grant Count 30
R01 Count 11
Funding $2,400,363.04
PubMed Score 42.29
PubTator Score 31.92

Knowledge Summary


No data available


  Differential Expression (17)

Disease log2 FC p
interstitial lung disease -1.100 0.044
malignant mesothelioma -5.400 0.000
osteosarcoma 2.090 0.001
cystic fibrosis -2.759 0.000
atypical teratoid / rhabdoid tumor -1.100 0.000
medulloblastoma -1.200 0.000
Duchenne muscular dystrophy -1.047 0.000
adrenocortical carcinoma -1.699 0.001
intraductal papillary-mucinous adenoma (... 1.600 0.015
interstitial cystitis -1.400 0.000
aldosterone-producing adenoma -1.480 0.018
lung adenocarcinoma 2.138 0.000
lung carcinoma 1.500 0.000
non-small cell lung carcinoma 1.300 0.000
Breast cancer -1.100 0.002
ovarian cancer 1.800 0.000
pituitary cancer -2.300 0.000

Gene RIF (27)

26717892 Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
26608079 Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
25936805 Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.
25843797 conclude that DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy
25810016 Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin expression
25605718 Receptor CXCR4 signaling promotes lysosomal and ESCRT-dependent degradation of DEPTOR, an antagonist of mTORC2, that regulates Akt activation and signaling.
25544749 Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.
25333702 our data provide evidence for the requirement of TGFbeta-activated mTORC1 only by deptor downregulation, which dominates upon the bystander mTORC2 activity for enhanced expression of collagen I (alpha2).
25258312 DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells
25119265 In Alzheimer's disease patients the mTOR pathway can be overactive, leading to a dysfunction of autophagy and a lack of amyloid beta clearance so the excess of amyloid beta will cause a further decrease in DEPTOR and an increase in mTOR expression.

AA Sequence


Text Mined References (45)

PMID Year Title
26717892 2016 Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation.
26608079 2016 Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.
25936805 2015 Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.
25843797 2015 DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells.
25810016 2015 Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin expression.
25605718 2015 The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.
25544749 2014 DEPTOR has growth suppression activity against pancreatic cancer cells.
25416956 2014 A proteome-scale map of the human interactome network.
25333702 2014 TGF?-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (?2) gene expression.
25258312 2014 DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells.