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  5. Stomatin-like protein 3

Tbio Stomatin-like protein 3

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 265.60
PubTator Score 18.07

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count P-value
psoriasis 6694 4.3e-19
nasopharyngeal carcinoma 1058 8.7e-06
ependymoma 4679 3.5e-03
chronic rhinosinusitis 512 2.4e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5
Disease Target Count Z-score Confidence
Metabolic syndrome X 52 0.0 1.2

Expression

  Differential Expression (4)

Disease log2 FC p
chronic rhinosinusitis -2.100 2.4e-02
ependymoma 1.500 3.5e-03
nasopharyngeal carcinoma -1.500 8.7e-06
psoriasis -2.200 4.3e-19

Synonym

Accession Q8TAV4 B4E285 Q5JS35 SLP-3
Symbols SRO
Epb7.2l

Gene

STOML3

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (8)

 GO Component (4)

 GO Process (2)

 Compartment GO Term (10)

 MGI Phenotype (3)

 GWAS Trait (2)

 HCA RNA Cell Line (15)

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Pathway (3)

Gene RIF (1)

AA Sequence 

MDSRVSSPEKQDKENFVGVNNKRLGVCGWILFSLSFLLVIITFPISIWMCLKIIKEYERAVVFRLGRIQA      1 - 70
DKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQAT     71 - 140
FLLAQTTLRNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEA    141 - 210
TREARAKVLAAEGEMNASKSLKSASMVLAESPIALQLRYLQTLSTVATEKNSTIVFPLPMNILEGIGGVS    211 - 280
YDNHKKLPNKA                                                               281 - 291
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Text Mined References (9)

PMID Year Title