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  4. Stomatin-like protein 3

Tdark Stomatin-like protein 3

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 233.40
PubTator Score 18.07

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (6)

Disease Z-score Confidence
gliosarcoma 19 3.168 1.6
Metabolic syndrome X 155 1.0
chronic rhinosinusitis 512
nasopharyngeal carcinoma 1,056
posterior fossa group B ependymoma 1,530
psoriasis 6,685

Expression

  Differential Expression (4)

Disease log2 FC p
posterior fossa group B ependymoma 3.600 0.000
nasopharyngeal carcinoma -1.500 0.000
chronic rhinosinusitis -2.100 0.024
psoriasis -2.200 0.000

Synonym

Accession Q8TAV4 B4E285 Q5JS35 SLP-3
Symbols SRO
Epb7.2l

Gene

STOML3

PANTHER Protein Class (1)

 GO Component (4)

 GO Process (1)

 Compartment GO Term (10)

 MGI Term (3)

Pathway (3)

 UniProt Keyword (8)

Gene RIF (1)

PMID Text
22538188 Amplification of the STOML3 gene is associated with mesenchymal differentiation in gliosarcoma.

AA Sequence 

MDSRVSSPEKQDKENFVGVNNKRLGVCGWILFSLSFLLVIITFPISIWMCLKIIKEYERAVVFRLGRIQA      1 - 70
DKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQAT     71 - 140
FLLAQTTLRNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEA    141 - 210
TREARAKVLAAEGEMNASKSLKSASMVLAESPIALQLRYLQTLSTVATEKNSTIVFPLPMNILEGIGGVS    211 - 280
YDNHKKLPNKA                                                               281 - 291
//

Text Mined References (9)

PMID Year Title
22538188 2012 Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma.
20694148 2010 A genome-wide association study of the metabolic syndrome in Indian Asian men.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057823 2004 The DNA sequence and analysis of human chromosome 13.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12122055 2002 Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.