Tbio LHFPL5 LHFPL tetraspan subfamily member 5 protein

Protein Summary

Description

In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TAF8
• B3KX66

Gene Name

• LHFPL5

Ensembl ID

• ENST00000360215
• ENSP00000353346
• ENSG00000197753
• ENST00000645222
• ENSP00000493955

Symbol

• TMHS
• TMHS
• DFNB67
• dJ510O8.8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
cell type or tissue	0.6
tissue	0.58
microRNA	0.55
tissue sample	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.19   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.19   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0