Property Summary

NCBI Gene PubMed Count 10
PubMed Score 14.59
PubTator Score 8.71

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
psoriasis 6685 2.80496753267345E-14
atypical teratoid/rhabdoid tumor 1095 5.21440445407547E-8
acute quadriplegic myopathy 1157 1.80222247384426E-6
sonic hedgehog group medulloblastoma 1482 4.36836715701032E-6
breast carcinoma 1614 2.6756526315906E-5
Atopic dermatitis 944 3.30694183424689E-5
pituitary cancer 1972 2.44983362570357E-4
Amyotrophic Lateral Sclerosis 432 4.41446134148339E-4
limb girdle muscular dystrophy 2A 156 4.8760991116696E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 8.17638660403418E-4
pediatric high grade glioma 2712 0.00100944473882403
subependymal giant cell astrocytoma 2287 0.00355770299899716
medulloblastoma, large-cell 6234 0.00452476216268446
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00582677311257395
primitive neuroectodermal tumor 3031 0.00671415627797554
glioblastoma 5572 0.00741127811453412
invasive ductal carcinoma 2950 0.00815675268809377
fibroadenoma 557 0.0105621187254673
ductal carcinoma in situ 1745 0.0148456078011845
aldosterone-producing adenoma 664 0.0364728462808675
Becker muscular dystrophy 187 0.039383234825044
Disease Target Count Z-score Confidence
Dental caries 67 0.0 1.0
Disease Target Count Z-score Confidence
Cardiac sarcoidosis 2 3.135 1.6
Mucosal melanoma 2 3.001 1.5



Accession Q8TAD2 B1AM69 IL-17D
Symbols IL-17D


  Ortholog (6)

Species Source
Mouse OMA EggNOG
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

Gene RIF (5)

24794441 Utilizing gene microarray analysis, authors found the cytokine interleukin 17D (IL-17D) was highly expressed in certain unedited tumors.
23490420 These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells.
22156348 IL-27 priming results in enhanced lipopolysaccharide-induced IL-6, tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta expression in human primary monocytes.
20237496 Observational study of gene-disease association. (HuGE Navigator)
12097364 IL-17D stimulates production of cytokines in endothelial cells in vitro and suppresses proliferation of myeloid progenitors in colony formation assays.

AA Sequence


Text Mined References (12)

PMID Year Title
24850809 2014 Genetic determinants of P wave duration and PR segment.
24794441 2014 Interleukin-17D mediates tumor rejection through recruitment of natural killer cells.
23490420 2013 The effects of IL-17 upon human natural killer cells.
23064961 2013 GWAS of dental caries patterns in the permanent dentition.
22156348 2012 IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057823 2004 The DNA sequence and analysis of human chromosome 13.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.