Property Summary

NCBI Gene PubMed Count 18
Grant Count 1
R01 Count 1
Funding $410,722
PubMed Score 154.18
PubTator Score 37.80

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (2)

Disease log2 FC p
osteosarcoma -1.229 0.000
pancreatic ductal adenocarcinoma liver m... -1.445 0.003

Gene RIF (12)

PMID Text
26189599 Serum ANGPTL6 levels increased in patients with a hypothyroid status, and both TSH and free T4 levels are associated with ANGPLT6 levels, suggesting a possible association between thyroid function and ANGPTL6 levels.
25011017 AGF concentrations is significantly higher in patients with type 2 diabetes as compared to controls.
23905605 In the second trimester, Angptl6 levels are higher in women with subsequent pregnancy-induced hypertension.
23718665 There are no significant differences in maternal Angptl6/ARP5 serum level between pre-eclamptic women and normally pregnant control women
23070965 Interaction between alpha6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6.
22406517 Serum AGF levels are significantly higher in subjects with polycystic ovary syndrome than those in the healthy control group.
21460784 ANGPTL6 affects resting metabolic rate (RMR), significantly improves lipid profile and slightly improves insulin levels and insulin sensitivity, as well.
20673930 serum AGF levels were paradoxically increased in metabolic syndrome, in comparison with data from animal experiments and data on sex, age, and waist circumference
19447061 study of associations between ANGPTL6 polymorphisms and metabolic syndrome or related phenotypes in a French population
16806062 Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism.
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AA Sequence

MGKPWLRALQLLLLLGASWARAGAPRCTYTFVLPPQKFTGAVCWSGPASTRATPEAANASELAALRMRVG      1 - 70
RHEELLRELQRLAAADGAVAGEVRALRKESRGLSARLGQLRAQLQHEAGPGAGPGADLGAEPAAALALLG     71 - 140
ERVLNASAEAQRAAARFHQLDVKFRELAQLVTQQSSLIARLERLCPGGAGGQQQVLPPPPLVPVVPVRLV    141 - 210
GSTSDTSRMLDPAPEPQRDQTQRQQEPMASPMPAGHPAVPTKPVGPWQDCAEARQAGHEQSGVYELRVGR    211 - 280
HVVSVWCEQQLEGGGWTVIQRRQDGSVNFFTTWQHYKAGFGRPDGEYWLGLEPVYQLTSRGDHELLVLLE    281 - 350
DWGGRGARAHYDGFSLEPESDHYRLRLGQYHGDAGDSLSWHNDKPFSTVDRDRDSYSGNCALYQRGGWWY    351 - 420
HACAHSNLNGVWHHGGHYRSRYQDGVYWAEFRGGAYSLRKAAMLIRPLKL                        421 - 470
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Text Mined References (21)

PMID Year Title
26189599 2015 Influence of thyroid dysfunction on serum levels of angiopoietin-like protein 6.
25011017 2014 Relationship between serum levels of angiopoietin-related growth factor and metabolic risk factors.
23905605 2013 Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study.
23718665 2013 Alterations of angiopoietin-related growth factor (Angptl6) during pregnancy and in pre-eclampsia.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23400010 2014 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
23070965 2012 A complex of ?6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6.
22406517 2012 Serum levels of angiopoietin-related growth factor (AGF) are increased in polycystic ovary syndrome.
21460784 2011 Evidence of a role of ANGPTL6 in resting metabolic rate and its potential application in treatment of obesity.
20673930 2011 Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome.
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