Tbio HUS1B Checkpoint protein HUS1B

Protein Summary

Description

The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NHY5
• Q5T4Z2
• hHUS1B

Gene Name

• HUS1B

Ensembl ID

• ENST00000380907
• ENSP00000370293
• ENSG00000188996

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.81
cell type or tissue	0.56
cellular component	0.53
biological process	0.51
cell line	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0