Tdark OTOS Otospiralin

Protein Summary

Description

May be essential for the survival of the neurosensory epithelium of the inner ear. Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NHW6
• Q53SW6

Gene Name

• OTOS

Ensembl ID

• ENST00000319460
• ENSP00000322486
• ENSG00000178602
• ENST00000391989
• ENSP00000375849

Symbol

• OTOSP
• OTOSP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.9
cell line	0.53
gene perturbation	0.44
tissue	0.43
transcription factor	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.96   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 39   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.96   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0