Property Summary

NCBI Gene PubMed Count 19
PubMed Score 24.77
PubTator Score 39.13

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 9.74237745290313E-17
non-small cell lung cancer 2798 6.33616202969098E-16
lung adenocarcinoma 2714 2.60816041912615E-9
pituitary cancer 1972 2.84261988929555E-8
Breast cancer 3099 1.11218025604675E-6
ovarian cancer 8492 1.67360664691105E-6
posterior fossa group B ependymoma 1530 2.42114710225686E-6
nasopharyngeal carcinoma 1056 2.86018257908336E-5
medulloblastoma, large-cell 6234 2.12964670468531E-4
hepatocellular carcinoma 550 6.80648826537572E-4
tuberculosis 1563 0.00170291628880921
osteosarcoma 7933 0.00222292651810835
group 3 medulloblastoma 2254 0.00486210176149201
spina bifida 1064 0.00811422598969312
active Crohn's disease 918 0.00898903036188619
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0188779709870841
active ulcerative colitis 477 0.0261615492690078
atypical teratoid / rhabdoid tumor 4369 0.0262986179102684
non diabetic and post-ischemic heart failure 200 0.0318114042582653
Rheumatoid Arthritis 1171 0.0480264093521853
Disease Target Count Z-score Confidence
Fetal alcohol spectrum disorder 6 3.461 1.7



Accession Q8NHU3 A8K2S9 B2RA61
Symbols SMS2


  Ortholog (12)

Gene RIF (15)

25231990 F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms-deficient cells.
25231990 SMS2 is involved in HIV-1 gp120-induced phosphorylation and activation of PYK2 and polymerization of F-actin
22106271 Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 and SMS2.
21980337 SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion
21235823 direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2
20332099 Observational study of gene-disease association. (HuGE Navigator)
19454763 Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.
19286635 Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.
19233134 These results suggested that posttranslational palmitoylation is important for determination of the subcellular localization of SMS2.
18694848 Both SMS1 and SMS2 contain two histidines and one aspartic acid which are conserved within the lipid phosphate phosphatase superfamily. Site-directed mutagenesis of these amino acids abolished SMS activity without altering cellular distribution.

AA Sequence

YSRVQKIGEDNEKST                                                           351 - 365

Text Mined References (22)

PMID Year Title
25231990 2014 Sphingomyelin synthase 2, but not sphingomyelin synthase 1, is involved in HIV-1 envelope-mediated membrane fusion.
22106271 2011 Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.
21980337 2011 Sphingomyelin synthases regulate protein trafficking and secretion.
21235823 2011 Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice.
20332099 2010 A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
19454763 2009 Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase.
19286635 2009 Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.
19233134 2009 Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes.
19001565 2008 An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis.
18694848 2008 The domain responsible for sphingomyelin synthase (SMS) activity.