Tchem SGMS2 Phosphatidylcholine:ceramide cholinephosphotransferase 2

Protein Summary

Description

Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q8NHU3
• A8K2S9
• B2RA61

Gene Name

• SGMS2

Ensembl ID

• ENST00000359079
• ENSP00000351981
• ENSG00000164023
• ENST00000394684
• ENSP00000378176
• ENST00000394686
• ENSP00000378178

Symbol

• SMS2
• SMS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.97
microRNA	0.69
transcription factor perturbation	0.68
PubMedID	0.66
cellular component	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.16   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.16   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0