Tbio Motile sperm domain-containing protein 2

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Promotes migration of primary monocytes and neutrophils, in response to various chemokines.

Property Summary

NCBI Gene PubMed Count	9
PubMed Score	1.60

Knowledge Summary

Patent

No data available

TINX Plot

Disease (3)

Disease	Target Count	P-value
lung cancer	4740	7.4e-04
progressive supranuclear palsy	676	1.5e-02

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.7

Disease	Target Count	Z-score	Confidence
Rheumatic heart disease	10	3.958	2.0
Rheumatic fever	19	3.92	2.0

Expression

Specificity
Differential

Differential Expression (2)

Disease	log2 FC	p
lung cancer	-1.200	7.4e-04
progressive supranuclear palsy	-1.400	1.5e-02

Brain - Spinal cord (cervical c-1) 17,973

Nerve - Tibial 18,007

Cells - Transformed fibroblasts 17,577

Vagina 17,834

Skin - Not Sun Exposed (Suprapubic) 18,081

Skin - Sun Exposed (Lower leg) 17,968

Thyroid 18,024

Ovary 17,971

Uterus 17,618

Adipose - Visceral (Omentum) 17,937

Adipose - Subcutaneous 18,110

Lung 18,057

Small Intestine - Terminal Ileum 17,954

Spleen 17,614

Artery - Coronary 17,949

Breast - Mammary Tissue 18,103

Artery - Aorta 17,896

Cells - EBV-transformed lymphocytes 18,186

Brain - Substantia nigra 17,981

Artery - Tibial 17,631

Brain - Cerebellar Hemisphere 18,015

Esophagus - Mucosa 18,076

Brain - Hippocampus 18,011

Colon - Sigmoid 18,089

Brain - Cerebellum 17,983

Esophagus - Gastroesophageal Junction 18,000

Brain - Hypothalamus 18,169

Brain - Putamen (basal ganglia) 17,863

Esophagus - Muscularis 18,017

Brain - Caudate (basal ganglia) 18,001

Brain - Nucleus accumbens (basal ganglia... 18,024

Whole Blood 17,439

Pituitary 18,147

Prostate 18,213

Brain - Amygdala 18,006

Brain - Frontal Cortex (BA9) 18,069

Adrenal Gland 18,071

Minor Salivary Gland 18,005

Colon - Transverse 17,825

Brain - Cortex 18,039

Testis 18,518

Brain - Anterior cingulate cortex (BA24) 17,989

Stomach 17,879

Heart - Atrial Appendage 17,896

Kidney - Cortex 17,329

Liver 18,071

Pancreas 18,123

Heart - Left Ventricle 18,006

Muscle - Skeletal 17,778

Monocytes 7,422

Adult Spinal Cord 7,594

Fetal Ovary 9,118

Fetal Testis 7,955

Adult Frontal Cortex 9,048

Adult Ovary 10,192

B Cells 9,086

Adult Testis 10,836

CD8 Cells 9,840

NK Cells 8,475

Adult Retina 10,115

Adult Lung 6,663

Adult Adrenal 8,475

Adult Liver 9,113

Platelets 6,131

Adult Colon 7,915

Fetal Heart 9,228

Fetal Brain 7,866

Adult Urinary Bladder 7,592

Adrenal gland

Blood platelet

Brain

Colon

Frontal lobe

Heart

Liver

Lung

B-lymphocyte

Monocyte

Natural killer cell

Ovary

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Amygdala 627

Testis 3,897

See source...

See source...

Synonym

Accession	Q8NHP6 Q8N3H2 Q8NA83
Symbols

Gene

MOSPD2

Ortholog (15)

Species	Source	Disease
Chimp 14,140	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Macaque 12,761	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Pig 10,168	Inparanoid OMA EggNOG
Chicken 7,827	Inparanoid OMA EggNOG
Platypus 5,703	OMA EggNOG
Xenopus 10,468	Inparanoid OMA EggNOG
Anole lizard 10,588	Inparanoid OMA EggNOG
C. elegans 3,179	Inparanoid OMA
Zebrafish 9,726	Inparanoid OMA EggNOG

UniProt Keyword (9)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

Cell membrane 3,390

Membrane 7,361

Transmembrane 5,228

Transmembrane helix 5,207

Chemotaxis 96

GO Component (4)

membrane 1,917

plasma membrane 4,414

integral component of plasma membrane 1,418

specific granule membrane 91

GO Process (4)

chemotaxis 119

positive regulation of neutrophil chemot... 29

neutrophil degranulation 484

positive regulation of monocyte chemotax... 22

Compartment GO Term (38)

Bounding membrane of organelle 1,956

Cell 16,178

Cell part 16,177

Cell periphery 5,382

Cytoplasm 10,983

Cytoplasmic part 9,247

Cytoplasmic vesicle 2,218

Cytoplasmic vesicle membrane 795

Cytoplasmic vesicle part 1,513

Endomembrane system 4,237

Endoplasmic reticulum 2,001

Integral component of membrane 5,331

Integral component of plasma membrane 1,693

Intracellular 14,109

Intracellular organelle 12,025

See all...

GWAS Trait (1)

Waist-to-hip circumference ratio (dietar... 3

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (3)

Immune System 2,101

Innate Immune System 1,176

Neutrophil degranulation 539

Gene RIF (1)

AA Sequence

MAENHAQNKAKLISETRRRFEAEYVTDKSDKYDARDVERLQQDDNWVESYLSWRHNIVDETLKMLDESFQ      1 - 70
WRKEISVNDLNESSIPRWLLEIGVIYLHGYDKEGNKLFWIRVKYHVKDQKTILDKKKLIAFWLERYAKRE     71 - 140
NGKPVTVMFDLSETGINSIDMDFVRFIINCFKVYYPKYLSKIVIFDMPWLMNAAFKIVKTWLGPEAVSLL    141 - 210
KFTSKNEVQDYVSVEYLPPHMGGTDPFKYSYPPLVDDDFQTPLCENGPITSEDETSSKEDIESDGKETLE    211 - 280
TISNEEQTPLLKKINPTESTSKAEENEKVDSKVKAFKKPLSVFKGPLLHISPAEELYFGSTESGEKKTLI    281 - 350
VLTNVTKNIVAFKVRTTAPEKYRVKPSNSSCDPGASVDIVVSPHGGLTVSAQDRFLIMAAEMEQSSGTGP    351 - 420
AELTQFWKEVPRNKVMEHRLRCHTVESSKPNTLTLKDNAFNMSDKTSEDICLQLSRLLESNRKLEDQVQR    421 - 490
CIWFQQLLLSLTMLLLAFVTSFFYLLYS                                              491 - 518
//

Text Mined References (12)

Summary
Details

	PMID	Year	Title