Property Summary

NCBI Gene PubMed Count 14
Grant Count 4
R01 Count 2
Funding $227,582.35
PubMed Score 4.07
PubTator Score 5.88

Knowledge Summary


No data available



Accession Q8NHG7


Gene RIF (4)

24100225 the interactions between P97 and these motifs, including VCP-binding motif (VBM) and VCP-interacting motif (VIM). The solution structures of the VBM motif from HRD1 and the VIM motif from SVIP are both comprised mainly of a single alpha-helix.
24055875 A major portion of SVIP is intrinsically disordered in solution.
21909394 SVIP plays a regulatory role in p97 subcellular localization and is a novel regulator of autophagy.
17872946 SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78-p97/VCP-Derlin1 complex.

AA Sequence

GLRWTVS                                                                    71 - 77

Text Mined References (17)

PMID Year Title
25660456 2015 Identification of ERAD components essential for dislocation of the null Hong Kong variant of ?-1-antitrypsin (NHK).
25255805 2014 Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
25085501 2014 Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.
24100225 2013 Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP.
24055875 2013 Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21909394 2011 SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.
21896481 2011 The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.
21546767 2011 Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.