Property Summary

NCBI Gene PubMed Count 16
PubMed Score 44.04
PubTator Score 20.89

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
ovarian cancer 8492 9.70699664485053E-8
posterior fossa group B ependymoma 1530 4.39914185123845E-7
osteosarcoma 7933 3.5191530192471E-6
group 3 medulloblastoma 2254 4.7613248095708E-4
Disease Target Count Z-score Confidence
Autistic Disorder 320 4.475 2.2
Schizophrenia 503 3.477 1.7

Expression

  Differential Expression (4)

Disease log2 FC p
osteosarcoma 1.543 0.000
group 3 medulloblastoma -1.200 0.000
posterior fossa group B ependymoma -1.100 0.000
ovarian cancer 1.800 0.000

Synonym

Accession Q8NFZ4 Q9P2I1
Symbols

Gene

PANTHER Protein Class (2)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid

 CSPA Cell Line (1)

Gene RIF (4)

PMID Text
24842555 Neuroligin-2 was down-regulated in aganglionic colonic segments from Hirschsprung's disease patients.
22528485 Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function
21551456 Data identified the R215H mutant as a loss-of-function mutant in inducing GABAergic synaptogenesis. Data also suggests that defects in GABAergic synapse formation in the brain may be an important contributing factor for the onset of schizophrenia.
19086053 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFL      1 - 70
GVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSED     71 - 140
CLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVA    141 - 210
TLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHS    211 - 280
EGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIA    281 - 350
FGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGY    351 - 420
PEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAE    421 - 490
GRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHT    491 - 560
KPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWP    561 - 630
PRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYK    631 - 700
RDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYT    701 - 770
LALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV         771 - 835
//

Text Mined References (19)

PMID Year Title
24842555 2014 The down-regulation of neuroligin-2 and the correlative clinical significance of serum GABA over-expression in Hirschsprung's disease.
24613359 2014 Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
23751499 2013 The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.
23248271 2013 MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
22528485 2012 Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic ? cell function.
21551456 2011 Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia.
19926856 2009 The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
18755801 2008 Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.
12669065 2003 Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
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