Tbio DMBX1 Diencephalon/mesencephalon homeobox protein 1

Protein Summary

Description

Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity). This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NFW5
• A6NNN2
• Q8NFW6
• Q8NHD9

Gene Name

• DMBX1

Ensembl ID

• ENST00000360032
• ENSP00000353132
• ENSG00000197587
• ENST00000371956
• ENSP00000361024

Symbol

• MBX
• OTX3
• PAXB
• MBX
• OTX3
• PAXB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
biological process	0.63
transcription factor	0.62
protein domain	0.58
molecular function	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.7   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.7   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0