Tdark TSTD1 Thiosulfate:glutathione sulfurtransferase

Protein Summary

Description

Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).

Uniprot Accession IDs

• Q8NFU3
• Q5SY48
• Q5SY49
• Q5SY50
• Q5SY51
• Q8NFU2
• Q9BV22
• TST

Gene Name

• TSTD1

Ensembl ID

• ENST00000318289
• ENSP00000325518
• ENSG00000215845
• ENST00000368023
• ENSP00000357002
• ENST00000368024
• ENSP00000357003
• ENST00000423014
• ENSP00000388293

Symbol

• KAT
• KAT
• TST

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
tissue sample	0.61
transcription factor perturbation	0.54
gene perturbation	0.47
cell type or tissue	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0