Tbio BEST4 Bestrophin-4

Protein Summary

Description

Forms calcium-sensitive chloride channels. Permeable to bicarbonate. This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NFU0
• Q5JR93

Gene Name

• BEST4

Ensembl ID

• ENST00000372207
• ENSP00000361281
• ENSG00000142959

Symbol

• VMD2L2
• VMD2L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.64
tissue sample	0.62
tissue	0.6
molecular function	0.53
metabolite	0.45

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Anion Channel / Bestrophin-4

DTO Classes

Protein / Ion Channel / Anion Channel-forming Bestrophin (Bestrophin) Family / Bestrophin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0