Tbio IL17RD Interleukin-17 receptor D

Protein Summary

Description

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q8NFM7
• Q2NKP7
• Q58EZ7
• Q6RVF4
• Q6UWI5
• Q8N113
• Q8NFS0
• Q9UFA0
• IL-17 receptor D

Gene Name

• IL17RD

Ensembl ID

• ENST00000296318
• ENSP00000296318
• ENSG00000144730
• ENST00000320057
• ENSP00000322250
• ENST00000463523
• ENSP00000417516
• ENST00000640796
• ENSP00000492817

Symbol

• IL17RLM
• SEF
• SEF
• HH18
• IL-17RD
• IL17RLM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.71
transcription factor perturbation	0.68
microRNA	0.65
PubMedID	0.65
transcription factor binding site profile	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.22   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.22   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0