Tchem ENGASE Cytosolic endo-beta-N-acetylglucosaminidase

Protein Summary

Description

Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8NFI3
• Q659F0
• Q8TB86
• Q9H6U4
• ENGase

Gene Name

• ENGASE

Ensembl ID

• ENST00000579016
• ENSP00000462333
• ENSG00000167280

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
histone modification site profile	0.82
tissue	0.64
tissue sample	0.61
cellular component	0.57

Protein Classes

PANTHER Classes

Protein / Hydrolase / Deaminase / Cytosolic Endo-beta-n-acetylglucosaminidase

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Cytosolic Endo-beta-n-acetylglucosaminidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.84   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.84   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0