Tbio DUSP18 Dual specificity protein phosphatase 18

Protein Summary

Description

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Uniprot Accession IDs

• Q8NEJ0
• B3KPA4

Gene Name

• DUSP18

Ensembl ID

• ENST00000334679
• ENSP00000333917
• ENSG00000167065
• ENST00000377087
• ENSP00000366291
• ENST00000404885
• ENSP00000385463
• ENST00000407308
• ENSP00000386063

Symbol

• LMWDSP20
• DSP18
• DUSP20
• LMWDSP20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
histone modification site profile	0.87
transcription factor perturbation	0.68
cell type or tissue	0.62
transcription factor	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 39   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0