Tbio | Dual specificity protein phosphatase 18 |
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 2.52216647743633E-5 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00943236191984604 |
ependymoma | 2514 | 0.0209382810704966 |
Disease | log2 FC | p |
---|---|---|
ependymoma | 1.500 | 0.021 |
osteosarcoma | -1.331 | 0.000 |
intraductal papillary-mucinous neoplasm ... | 1.200 | 0.009 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG |
Anole lizard | OMA EggNOG |
Zebrafish | OMA EggNOG |
PMID | Year | Title |
---|---|---|
24531476 | 2014 | The family-wide structure and function of human dual-specificity protein phosphatases. |
19228121 | 2009 | Dual-specificity phosphatases: critical regulators with diverse cellular targets. |
16720344 | 2006 | Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. |
16699184 | 2006 | Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15461802 | 2004 | A genome annotation-driven approach to cloning the human ORFeome. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12591617 | 2003 | Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
12408986 | 2002 | Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. |