Tbio DENND6B Protein DENND6B

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

Uniprot Accession IDs

• Q8NEG7
• A6X8I5

Gene Name

• DENND6B

Ensembl ID

• ENST00000413817
• ENSP00000391524
• ENSG00000205593

Symbol

• FAM116B
• AFI1B
• FAM116B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
transcription factor binding site profile	0.75
interacting protein	0.65
cell type or tissue	0.63
cell line	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.77   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.77   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0