Tchem CATSPER1 Cation channel sperm-associated protein 1

Protein Summary

Description

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NEC5
• Q96P76
• CatSper1

Gene Name

• CATSPER1

Ensembl ID

• ENST00000312106
• ENSP00000309052
• ENSG00000175294

Symbol

• SPGF7
• CATSPER

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
gene perturbation	0.76
cellular component	0.67
biological process	0.6
tissue	0.58

Protein Classes

DTO Classes

Protein / Ion Channel / Cation Channel Sperm-associated Family / Cation Channel Sperm-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.32   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.32   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3