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Tbio
ABCF1
ATP-binding cassette sub-family F member 1

Protein Summary
Description
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326195
  • ENSP00000313603
  • ENSG00000204574
  • ENST00000376545
  • ENSP00000365728
  • ENST00000383587
  • ENSP00000373081
  • ENSG00000206490
  • ENST00000383588
  • ENSP00000373082
  • ENST00000412443
  • ENSP00000404726
  • ENSG00000236342
  • ENST00000419893
  • ENSP00000389065
  • ENSG00000232169
  • ENST00000420257
  • ENSP00000391102
  • ENSG00000225989
  • ENST00000421042
  • ENSP00000393143
  • ENSG00000231129
  • ENST00000423247
  • ENSP00000411327
  • ENST00000426219
  • ENSP00000414373
  • ENST00000448939
  • ENSP00000403526
  • ENST00000452530
  • ENSP00000389472
  • ENSG00000236149
  • ENST00000457078
  • ENSP00000412553
  • ENST00000457111
  • ENSP00000413319

Symbol
  • ABC50
  • ABC27
  • ABC50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
1
interacting protein
0.99
molecular function
0.96
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0