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Tdark C2 calcium-dependent domain-containing protein 4A

May be involved in inflammatory process. May regulate cell architecture and adhesion.

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 2.19
PubTator Score 2.58

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Diabetes Mellitus, Type 2 142 0.0 0.0
Disease Target Count Z-score Confidence
Acquired metabolic disease 336 0.0 3.0
Type 2 diabetes mellitus 272 0.0 3.0

Expression

  Differential Expression (11)

Disease log2 FC p
active Crohn's disease 4.110 7.0e-03
active ulcerative colitis 3.693 4.5e-03
Breast cancer 1.500 3.7e-03
ductal carcinoma in situ 1.500 2.5e-02
Endometriosis -2.284 1.7e-02
head and neck cancer 1.600 2.7e-06
intraductal papillary-mucinous carcinoma... 3.500 4.3e-04
intraductal papillary-mucinous neoplasm ... 2.800 4.4e-03
non-small cell lung cancer 1.271 1.8e-07
pituitary cancer -3.700 3.7e-06
psoriasis 1.500 2.6e-19

Synonym

Accession Q8NCU7
Symbols NLF1
FAM148A

Gene

C2CD4A

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 UniProt Keyword (3)

 GO Function (2)

 GO Component (2)

 Compartment GO Term (13)

 HCA RNA Cell Line (56)

See all...

Gene RIF (6)

AA Sequence 

MWCLERLRLGPECLRRSGDWLLPGRARGAKSRTTAACANVLTPDRIPEFCIPPRLMPRLALAALRNSWVE      1 - 70
EAGMDEGAGRTDWDPRSQAALSLPHLPRVRTAYGFCALLESPHTRRKESLLLGGPPAPRPRAHTYGGGGG     71 - 140
PDALLGTLRVPRAPGPATPAAPGCPRPPQDALARRPRGCRLLRVPDGLLSRALRAGRSRRLTRVRSVSSG    141 - 210
NEDKERRAGSQSPARAPSTSPPSSRVPFPERLEAEGTVALGRAGDALRLAAEYCPGTGRLRLRLLRAESP    211 - 280
AGGAPGPRAVSCRLSLVLRPPGTALRQCSTVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGR    281 - 350
ERGRLLGQGELSLGALLLL                                                       351 - 369
//

Text Mined References (12)

PMID Year Title