Tbio B3GALNT2 UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

Protein Summary

Description

Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carbohydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• Q8NCR0
• Q59GR3
• Q5TCI3
• Q96AL7
• Beta-1,3-GalNAc-T2

Gene Name

• B3GALNT2

Ensembl ID

• ENST00000313984
• ENSP00000315678
• ENSG00000162885
• ENST00000366600
• ENSP00000355559
• ENST00000635244
• ENSP00000489219
• ENSG00000282880
• ENST00000635453
• ENSP00000489342

Symbol

• MDDGA11
• B3GalNAc-T2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
transcription factor binding site profile	0.92
histone modification site profile	0.88
transcription factor perturbation	0.8
microRNA	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Udp-galnac:beta-1,3-n-acetylgalactosaminyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Udp-galnac:beta-1,3-n-acetylgalactosaminyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.66   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.66   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0