Tchem DAGLB Sn1-specific diacylglycerol lipase beta

Protein Summary

Description

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Uniprot Accession IDs

• Q8NCG7
• A4D2P3
• B3KV90
• B4DQU0
• Q6PIX3
• Q8N2N2
• Q8N9S1
• Q8TED3
• Q8WXE6
• DGL-beta

Gene Name

• DAGLB

Ensembl ID

• ENST00000297056
• ENSP00000297056
• ENSG00000164535
• ENST00000425398
• ENSP00000391171

Symbol

• KCCR13L
• DAGLBETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
metabolite	0.82
transcription factor perturbation	0.68
tissue sample	0.67
transcription factor binding site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.13   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.13   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1