Tchem | Sn1-specific diacylglycerol lipase beta |
Comments
Disease | Target Count | P-value |
---|---|---|
medulloblastoma, large-cell | 6234 | 7.66920153684422E-6 |
osteosarcoma | 7933 | 1.35318464786196E-4 |
primary pancreatic ductal adenocarcinoma | 1271 | 0.00387438580480554 |
aldosterone-producing adenoma | 664 | 0.0219203979655778 |
gastric carcinoma | 832 | 0.0378717858635052 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Cannabis dependence | 18 | 4.342 | 2.2 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -1.878 | 0.000 |
medulloblastoma, large-cell | -1.100 | 0.000 |
primary pancreatic ductal adenocarcinoma | 1.165 | 0.004 |
aldosterone-producing adenoma | -1.060 | 0.022 |
gastric carcinoma | 1.300 | 0.038 |
Species | Source |
---|---|
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
C. elegans | OMA EggNOG |
CHEMBL3765421
pIC50 6.84
CHEMBL3765022
pIC50 6.95
CHEMBL3764093
pIC50 7.10
CHEMBL158897
pIC50 7.22
CHEMBL3764017
pIC50 7.40
CHEMBL3764876
pIC50 7.40
AID | Type | Active / Inconclusive / Inactive | Description |
---|---|---|---|
504411 | screening |
203 / 0 / 343497 | Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB) |
504445 | screening |
141 / 0 / 51 | Fluorescence-based biochemical high throughput confirmation assay for inhibitors of human diacylglycerol lipase, beta (DAGLB) |
PMID | Text |
---|---|
22190034 | HIV-1 Vpu is identified to have a physical interaction with diacylglycerol lipase, beta (DAGLB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
14610053 | This gene has been functionally characterized as a diacylglycerol-lipase (DAGL), referred to as DAGL beta. These enzymes may have a role in the biosynthesis of the endocannabinoid 2-arachidnoyl glycerol (2-AG). |
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVI 1 - 70 CTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVS 71 - 140 WIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHT 141 - 210 RVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHH 211 - 280 YMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFH 281 - 350 DKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI 351 - 420 NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSL 421 - 490 VLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLL 491 - 560 GEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKIL 561 - 630 IGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA 631 - 672 //
PMID | Year | Title |
---|---|---|
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
24097068 | 2013 | Discovery and refinement of loci associated with lipid levels. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
18691976 | 2008 | Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
17897319 | 2007 | Integral and associated lysosomal membrane proteins. |
16806233 | 2007 | Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |
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