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Tchem Sn1-specific diacylglycerol lipase beta

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

 Comments

Property Summary

NCBI Gene PubMed Count 11
Grant Count 2
Funding $70,771
PubMed Score 15.60
PubTator Score 4.51

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (7)

Disease Z-score Confidence
Cannabis dependence 18 4.342 2.2
Obesity 616
aldosterone-producing adenoma 664
gastric carcinoma 832
medulloblastoma, large-cell 6,234
osteosarcoma 7,933
primary pancreatic ductal adenocarcinoma 1,271

Expression

  Differential Expression (5)

Disease log2 FC p
osteosarcoma -1.878 0.000
medulloblastoma, large-cell -1.100 0.000
primary pancreatic ductal adenocarcinoma 1.165 0.004
aldosterone-producing adenoma -1.060 0.022
gastric carcinoma 1.300 0.038

Synonym

Accession Q8NCG7 A4D2P3 B3KV90 B4DQU0 Q6PIX3 Q8N2N2 Q8N9S1 Q8TED3 Q8WXE6 DGL-beta
Symbols KCCR13L
DAGLBETA

Gene

DAGLB

 Grant Application (2)

 GO Function (2)

 GO Component (3)

 GO Process (4)

 Compartment GO Term (29)

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 MGI Term (3)

 GWAS Trait (1)

Pathway (13)

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 UniProt Keyword (14)

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Drug (1)

Structure of orlistat

orlistat
pIC50 7.22

Ligand (6)

Structure of CHEMBL3765421

CHEMBL3765421
pIC50 6.84

Structure of CHEMBL3765022

CHEMBL3765022
pIC50 6.95

Structure of CHEMBL3764093

CHEMBL3764093
pIC50 7.10

Structure of CHEMBL158897

CHEMBL158897
pIC50 7.22

Structure of CHEMBL3764017

CHEMBL3764017
pIC50 7.40

Structure of CHEMBL3764876

CHEMBL3764876
pIC50 7.40

MLP Assay (2)

AID Type Active / Inconclusive / Inactive Description
504411 screening 203 / 0 / 343497 Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB)
504445 screening 141 / 0 / 51 Fluorescence-based biochemical high throughput confirmation assay for inhibitors of human diacylglycerol lipase, beta (DAGLB)

Gene RIF (2)

PMID Text
22190034 HIV-1 Vpu is identified to have a physical interaction with diacylglycerol lipase, beta (DAGLB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
14610053 This gene has been functionally characterized as a diacylglycerol-lipase (DAGL), referred to as DAGL beta. These enzymes may have a role in the biosynthesis of the endocannabinoid 2-arachidnoyl glycerol (2-AG).

AA Sequence 

MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVI      1 - 70
CTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVS     71 - 140
WIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHT    141 - 210
RVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHH    211 - 280
YMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFH    281 - 350
DKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI    351 - 420
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSL    421 - 490
VLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLL    491 - 560
GEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKIL    561 - 630
IGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA                                631 - 672
//

Text Mined References (19)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24097068 2013 Discovery and refinement of loci associated with lipid levels.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17897319 2007 Integral and associated lysosomal membrane proteins.
16806233 2007 Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.
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