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Tchem Sn1-specific diacylglycerol lipase beta

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

 Comments

Property Summary

Ligand Count 8
NCBI Gene PubMed Count 12
PubMed Score 14.47
PubTator Score 4.51

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count
Obesity 678
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Cannabis dependence 23 4.327 2.2

Expression

  Differential Expression (5)

Disease log2 FC p
aldosterone-producing adenoma -1.060 2.2e-02
gastric carcinoma 1.300 3.8e-02
medulloblastoma, large-cell -1.100 7.7e-06
osteosarcoma -1.878 1.4e-04
primary pancreatic ductal adenocarcinoma 1.165 3.9e-03

Synonym

Accession Q8NCG7 A4D2P3 B3KV90 B4DQU0 Q6PIX3 Q8N2N2 Q8N9S1 Q8TED3 Q8WXE6 DGL-beta
Symbols KCCR13L
DAGLBETA

Gene

DAGLB

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG

 UniProt Keyword (14)

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 GO Function (2)

 GO Component (4)

 GO Process (4)

 Compartment GO Term (16)

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 MGI Phenotype (3)

 GWAS Trait (5)

 HCA RNA Cell Line (56)

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Pathway (12)

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Drug (1)

Structure of orlistat

orlistat
pIC50 7.22

Ligand (6)

Structure of CHEMBL3765421

CHEMBL3765421
pIC50 6.84

Structure of CHEMBL3765022

CHEMBL3765022
pIC50 6.95

Structure of CHEMBL3764093

CHEMBL3764093
pIC50 7.10

Structure of CHEMBL158897

CHEMBL158897
pIC50 7.22

Structure of CHEMBL3764017

CHEMBL3764017
pIC50 7.40

Structure of CHEMBL3764876

CHEMBL3764876
pIC50 7.40

Gene RIF (3)

AA Sequence 

MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVI      1 - 70
CTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVS     71 - 140
WIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHT    141 - 210
RVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHH    211 - 280
YMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFH    281 - 350
DKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI    351 - 420
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSL    421 - 490
VLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLL    491 - 560
GEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKIL    561 - 630
IGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA                                631 - 672
//

Text Mined References (20)

PMID Year Title