Tchem Sn1-specific diacylglycerol lipase beta

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Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Comments

Property Summary

Ligand Count	9
NCBI Gene PubMed Count	12
PubMed Score	14.47

PubTator Score	4.51

Knowledge Summary

Patent

No data available

TINX Plot

Disease (4)

Disease	Target Count
Obesity	678

Disease	Target Count	P-value
medulloblastoma, large-cell	6241	7.7e-06
osteosarcoma	7950	1.4e-04
primary pancreatic ductal adenocarcinoma	1109	3.9e-03
aldosterone-producing adenoma	665	2.2e-02
gastric carcinoma	807	3.8e-02

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.7

Disease	Target Count	Z-score	Confidence
Cannabis dependence	23	4.327	2.2

Differential Expression (5)

Disease	log2 FC	p
aldosterone-producing adenoma	-1.060	2.2e-02
gastric carcinoma	1.300	3.8e-02
medulloblastoma, large-cell	-1.100	7.7e-06
osteosarcoma	-1.878	1.4e-04
primary pancreatic ductal adenocarcinoma	1.165	3.9e-03

Adrenal Gland 18,071

Skin - Sun Exposed (Lower leg) 17,968

Spleen 17,614

Lung 18,057

Skin - Not Sun Exposed (Suprapubic) 18,081

Brain - Cerebellar Hemisphere 18,015

Brain - Cerebellum 17,983

Uterus 17,618

Brain - Frontal Cortex (BA9) 18,069

Thyroid 18,024

Ovary 17,971

Vagina 17,834

Nerve - Tibial 18,007

Small Intestine - Terminal Ileum 17,954

Brain - Cortex 18,039

Cells - Transformed fibroblasts 17,577

Testis 18,518

Esophagus - Mucosa 18,076

Prostate 18,213

Adipose - Subcutaneous 18,110

Breast - Mammary Tissue 18,103

Brain - Nucleus accumbens (basal ganglia... 18,024

Adipose - Visceral (Omentum) 17,937

Whole Blood 17,439

Artery - Coronary 17,949

Brain - Spinal cord (cervical c-1) 17,973

Brain - Anterior cingulate cortex (BA24) 17,989

Colon - Sigmoid 18,089

Pituitary 18,147

Artery - Aorta 17,896

Brain - Caudate (basal ganglia) 18,001

Minor Salivary Gland 18,005

Brain - Hypothalamus 18,169

Esophagus - Gastroesophageal Junction 18,000

Colon - Transverse 17,825

Stomach 17,879

Cells - EBV-transformed lymphocytes 18,186

Brain - Putamen (basal ganglia) 17,863

Esophagus - Muscularis 18,017

Artery - Tibial 17,631

Brain - Hippocampus 18,011

Brain - Substantia nigra 17,981

Brain - Amygdala 18,006

Liver 18,071

Muscle - Skeletal 17,778

Heart - Atrial Appendage 17,896

Pancreas 18,123

Kidney - Cortex 17,329

Heart - Left Ventricle 18,006

Monocytes 7,422

Adult Frontal Cortex 9,048

Adult Testis 10,836

B Cells 9,086

Adult Adrenal 8,475

Adult Esophagus 4,936

CD8 Cells 9,840

Fetal Testis 7,955

Fetal Ovary 9,118

Adult Colon 7,915

CD4 Cells 7,773

Adult Heart 6,506

Adult Liver 9,113

Adult Lung 6,663

Fetal Liver 8,402

Adult Ovary 10,192

Adult Retina 10,115

Adult Gallbladder 7,612

Adult Urinary Bladder 7,592

Adrenal gland

Frontal lobe

Heart

Liver

Lung

B-lymphocyte

Monocyte

Esophagus

Ovary

Placenta 6,083

Retina

Testis

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Cervical carcinoma cell 4,944

BTO:0000379 352

Erythroleukemia cell 4,300

Liver 5,008

Placenta 3,079

Testis 3,897

Trachea 525

T-cell chronic lymphocytic leukemia cell 2,346

See source...

Synonym

Accession	Q8NCG7 A4D2P3 B3KV90 B4DQU0 Q6PIX3 Q8N2N2 Q8N9S1 Q8TED3 Q8WXE6 DGL-beta
Symbols	KCCR13L DAGLBETA

Gene

DAGLB

Ortholog (13)

Species	Source	Disease
Xenopus 10,463	OMA EggNOG
Zebrafish 9,725	Inparanoid OMA EggNOG
C. elegans 3,178	OMA EggNOG
Macaque 12,758	OMA EggNOG
Mouse 16,567	Inparanoid OMA EggNOG
Rat 15,112	Inparanoid OMA EggNOG
Dog 15,069	Inparanoid OMA EggNOG
Horse 14,249	Inparanoid OMA EggNOG
Cow 15,316	Inparanoid OMA EggNOG
Pig 10,164	OMA EggNOG
Opossum 12,223	Inparanoid OMA EggNOG
Platypus 5,699	Inparanoid OMA EggNOG
Chicken 7,823	Inparanoid OMA

UniProt Keyword (14)

Complete proteome 20,231

Metal-binding 3,672

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

Phosphoprotein 8,216

Cell membrane 3,390

Membrane 7,361

Transmembrane 5,228

Transmembrane helix 5,207

See all...

GO Function (2)

metal ion binding 2,256

acylglycerol lipase activity 10

GO Component (4)

nucleus 5,097

plasma membrane 4,414

integral component of membrane 3,665

lysosomal membrane 301

GO Process (4)

lipid catabolic process 73

neuroblast proliferation 16

arachidonic acid metabolic process 24

neurotransmitter biosynthetic process 13

Compartment GO Term (16)

Cell 16,178

Cell part 16,177

Cell periphery 5,382

Integral component of membrane 5,331

Intracellular 14,108

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

Intracellular part 13,972

Intrinsic component of membrane 5,458

Membrane 8,531

Membrane part 6,554

Nucleus 7,562

Organelle 12,238

Plasma membrane 5,830

cellular_component 18,320

See all...

MGI Phenotype (3)

homeostasis-metabolism phenotype 4,747

cellular phenotype 3,637

nervous system phenotype 3,447

GWAS Trait (5)

Coronary artery disease 367

HDL cholesterol 116

HDL cholesterol levels 66

Neutrophil percentage of white cells 121

Lymphocyte percentage of white cells 122

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (12)

Aldosterone synthesis and secretion 99

Retrograde endocannabinoid signaling 148

http://pathwaycommons.org/pc2/Pathway_a9... 33

Signal Transduction 2,657

GPCR downstream signalling 1,157

Signaling by GPCR 1,217

Hemostasis 666

Platelet activation, signaling and aggre... 256

G alpha (q) signalling events 211

Arachidonate production from DAG 4

See all...

Drug (2)

orlistat
pIC50 7.22

orlistat
pIC50 6.38

Ligand (6)

CHEMBL3765421
pIC50 6.84

CHEMBL3765022
pIC50 6.95

CHEMBL3764093
pIC50 7.10

CHEMBL158897
pIC50 7.22

CHEMBL3764017
pIC50 7.40

CHEMBL3764876
pIC50 7.40

Gene RIF (3)

AA Sequence

MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVI      1 - 70
CTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVS     71 - 140
WIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHT    141 - 210
RVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHH    211 - 280
YMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFH    281 - 350
DKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI    351 - 420
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSL    421 - 490
VLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLL    491 - 560
GEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKIL    561 - 630
IGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA                                631 - 672
//

Text Mined References (20)

Summary
Details

	PMID	Year	Title

Tchem Sn1-specific diacylglycerol lipase beta Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (4)

Expression

Differential Expression (5)

Synonym

Gene

Ortholog (13)

UniProt Keyword (14)

GO Function (2)

GO Component (4)

GO Process (4)

Compartment GO Term (16)

MGI Phenotype (3)

GWAS Trait (5)

HCA RNA Cell Line (56)

Pathway (12)

Drug (2)

Ligand (6)

Gene RIF (3)

AA Sequence

Text Mined References (20)

Tchem Sn1-specific diacylglycerol lipase beta

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