Property Summary

NCBI Gene PubMed Count 10
PubMed Score 1.40
PubTator Score 2.73

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 1.44952859834054E-30
ovarian cancer 8492 3.6522637345769E-9
Pick disease 1893 3.97936374049405E-5
medulloblastoma, large-cell 6234 0.00142865570128872
subependymal giant cell astrocytoma 2287 0.0221681792625533
Disease Target Count Z-score Confidence
Hereditary spherocytosis 20 3.883 1.9


  Differential Expression (5)

Disease log2 FC p
medulloblastoma, large-cell -1.100 0.001
subependymal giant cell astrocytoma -1.644 0.022
lung carcinoma 1.700 0.000
Pick disease -1.400 0.000
ovarian cancer -2.600 0.000


Accession Q8NC69 B3KNI5 Q8NBS6 Q8TCA6
Symbols KCASH3


PANTHER Protein Class (1)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (3)

24307990 A biophysical characterization of the POZ/BTB of KCTD6, is reported.
22573887 Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover
21472142 Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis.

AA Sequence

HHMSERANENTVEHNWTFCRLARKTDD                                               211 - 237

Text Mined References (10)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24307990 2013 Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization.
22573887 2012 Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.
21472142 2011 Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.