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Tbio
POMGNT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Protein Summary
Description
O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. This gene encodes a protein with glycosyltransferase activity although its function is not currently known. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344697
  • ENSP00000344125
  • ENSG00000144647
  • ENST00000441964
  • ENSP00000408992

Symbol
  • AGO61
  • C3orf39
  • EOGTL
  • GTDC2
  • AGO61
  • GTDC2
  • MDDGA8
  • MDDGC8
  • C3orf39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
cellular component
0.63
histone modification site profile
0.59
cell type or tissue
0.56
phenotype
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0