Tdark TRIML1 Probable E3 ubiquitin-protein ligase TRIML1

Protein Summary

Description

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q8N9V2
• Q96BE5

Gene Name

• TRIML1

Ensembl ID

• ENST00000332517
• ENSP00000327738
• ENSG00000184108

Symbol

• RNF209
• RNF209

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
protein domain	0.97
cell type or tissue	0.72
cellular component	0.64
cell line	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0