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Tbio
ZIC4
Zinc finger protein ZIC 4

Protein Summary
Description
Binds to DNA. This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383075
  • ENSP00000372553
  • ENSG00000174963
  • ENST00000425731
  • ENSP00000397695
  • ENST00000473123
  • ENSP00000420775
  • ENST00000484399
  • ENSP00000417855
  • ENST00000491672
  • ENSP00000418277
  • ENST00000525172
  • ENSP00000435509
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.67
PubMedID
0.57
transcription factor
0.54
gene perturbation
0.52
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.07   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.07   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0