Property Summary

NCBI Gene PubMed Count 35
Grant Count 24
R01 Count 18
Funding $2,186,408.1
PubMed Score 350.00
PubTator Score 28.47

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (7)

Disease log2 FC p
glioblastoma 1.200 0.000
lung carcinoma -1.800 0.000
acute myeloid leukemia 1.700 0.043
ulcerative colitis 1.200 0.000
Breast cancer 1.600 0.000
head and neck cancer and chronic obstruc... 1.200 0.001
psoriasis 1.700 0.000

 GO Component (1)

Gene RIF (32)

PMID Text
26893169 A STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses.
26867174 cGAS and STING are intracellular sensors that activate the interferon pathway in response to virus infection. [review]
26819496 cGAS silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (MMPs) as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes
26811480 By directly binding to cGAS, LANA, and particularly, a cytoplasmic isoform, inhibit the cGAS-STING-dependent phosphorylation of TBK1 and IRF3 and thereby antagonize the cGAS-mediated restriction of KSHV lytic replication.
26506431 TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I
26320998 Kaposi's sarcoma-associated herpesvirus ORF52 subverts cytosolic DNA sensing by directly inhibiting cGAS enzymatic activity through a mechanism involving both cGAS binding and DNA binding.
26311870 Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells.
26199418 Gammaherpesviruses encode inhibitors that block cGAS-STING-mediated antiviral immunity.
26048138 cGAS is an innate sensor of Mycobacterium tuberculosis.Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1.
26048137 M. tuberculosis infection induces cGAS in macrophages and human lung tissue.
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AA Sequence

MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQE      1 - 70
RPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWD     71 - 140
VPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN    141 - 210
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKF    211 - 280
RKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRK    281 - 350
QLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL    351 - 420
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNL    421 - 490
FSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF                                          491 - 522
//

Text Mined References (41)

PMID Year Title
26893169 2016 Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.
26867174 2016 The cGAS-STING Defense Pathway and Its Counteraction by Viruses.
26819496 2015 Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes.
26811480 2016 Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS.
26506431 2015 TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
26320998 2015 Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein.
26311870 2015 Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells.
26300263 2015 Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
26229115 2015 Transmission of innate immune signaling by packaging of cGAMP in viral particles.
26199418 2015 Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.
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